Doctoral Researcher in β-Catenin Ligands & Cell Differentiation

Doctorat / PhD Type de contrat : ["FULL_TIME","TEMPORARY"] Date limite de candidature : 2026-11-30T14:34:00.000Z

About us The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Faculty of Science, Technology and Medicine (FSTM) at the University of Luxembourg contributes multidisciplinary expertise in the fields of Mathematics, Physics, Engineering, Computer Science, Life Sciences and Medicine. Through its dual mission of teaching and research, the FSTM seeks to generate and disseminate knowledge and train new generations of responsible citizens in order to better understand, explain and advance society and the environment we live in. Your role Determine the specific impact of Wnt signalling on C2C12 progenitors and differentiation Develop dedicated BRET biosensors to measure intracellular protein-protein interactions in the Wnt pathway Investigate the impact of developed peptidic ligands on Wnt/β-catenin signalling and differentiation in C2C12 cells Measure: cellular differentiation, signalling responses and β-catenin localisation Build: BRET biosensors for target engagement and molecular events Integrate: cellular read-outs with ligand optimisation in the wider FlexCAT programme β-catenin is a central regulator of cell differentiation and stemness. Aberrant Wnt/β-catenin activity can drive developmental defects and cancer. This project tests whether context-specific peptidic ligands targeting β-catenin can restore aberrant differentiation. Using C2C12 myoblasts, you will combine cellular differentiation assays, signalling and confocal localisation studies with dedicated BRET biosensors to measure intracellular protein-protein interactions and target engagement. The resulting mechanistic read-outs will feed back into iterative β-catenin ligand optimisation within FlexCAT. Your profile MSc in Biochemistry, Developmental Biology, Biophysical Chemistry or a related field, with excellent results, qualifying for doctoral admission Good knowledge of molecular biochemistry, fluorescence microscopy and/or bioluminescence experiments applied to cell biology Basic cell-culture skills; experience with cellular differentiation models is an asset Strong project organisation, communication and collaborative skills MSCA mobility rule: normally no more than 12 months of residence/main activity in the recruiting country during the 36 months before recruitment Motivation for multidisciplinary international research, hands-on experimental work, secondment, publications, conferences and dissemination Operational Language Requirements: Excellent knowledge of English is required Academic Eligibility (Thesis): Applicants must demonstrate at least B2-level proficiency in the language of their thesis. For details and accepted certificates, please visit the Application for admission - Doctoral Candidates . We offer A modern, dynamic university with a personal and inclusive atmosphere.…