Doctoral Position: Development of an Organ-on-chip platform

Doctorat / PhD Conditions : 100%, Basel, fixed-term

The Bioanalytics Group at ETH Zürich in Basel (Switzerland) is developing so-called lab-on-chip technology (or microfluidic technology) for applications across the life sciences and biomedicine. Our interdisciplinary approach includes the design and manufacturing of miniaturized platforms and their optimization for biochemical assays and analytical procedures. To strengthen our team, we are offering a Doctoral Position for developing an organ-on-chip model system.

Organ-on-chip systems, also known as microphysiological systems, are promising platforms for investigating disease development and evaluating potential treatments. Their miniaturized design enables the reproducible and controlled formation of human tissues with specific functions, as well as the parallelized study of biological processes. In the Bioanalytics Group, we are developing vascularized tissue models to investigate how cells, cell-secreted molecules, and drugs cross the endothelial barrier to reach surrounding tissues and how compounds translocate from tissue into the blood stream. As part of a project focused on understanding the mechanisms underlying cancer metastasis, we are looking for a motivated Doctoral student interested in experimental research at the interface of engineering and biology.

Design and manufacture a microfluidic platform Develop, optimize and test biological assays Perform imaging (time-lapse microscopy), data analysis and interpretation Publish findings in peer-reviewed journals Participate actively in group meetings and collaborative research discussion meeting Interact and collaborate with other members of the group and collaboration partners

Master`s degree in microsystems engineering, biomedical engineering or interdisciplinary study programmes Candidates with background in biology, bioengineering, biotechnology, material sciences or microbiology, with a strong interest in technology development, are welcome to apply as well Experiences in the field of microfluidics The combination of biological and technological aspects is central in our group and in this project A possible candidate should have strong disposition to learn and improve novel methods, should be very open to different research disciplines and should be able to communicate across disciplines Good communication (in English) and teamwork skills

An intellectually challenging position in the inspiring atmosphere of an interdisciplinary team, and the prospect to obtain a Doctoral degree from ETH Zurich Applied work in a multidisciplinary team Advanced training in different related fields and participation at international conferences is highly encouraged

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