Predoctoral position in biomedical research in rare diseases

Doctorat / PhD Profil chercheur : First Stage Researcher (R1) Type de contrat : Temporary Date limite de candidature : 30 Nov 2026 - 23:59 (Europe/Madrid) Date de début : 1 Mar 2027 Programme UE : Not funded by a EU programme Département : Science Faculty, Molecular Biology Department Domaine : Biological sciences

PhD position focused on the study of the molecular, biochemical, and cellular mechanisms involved in neurometabolic diseases, with particular emphasis on propionic acidemia, using human models derived from induced pluripotent stem cells (iPSCs). The project will include the generation and characterization of cerebral organoids to investigate the molecular and biochemical phenotype associated with the disease, as well as the evaluation of potential therapeutic strategies targeting altered cellular pathways, including pharmacological compounds and miRNA-based approaches. In addition, the research will address the study and correction of splicing defects caused by variants identified in patients with neurometabolic diseases through the use of antisense oligonucleotides and gene-editing strategies. Responsibilities will include the culture and differentiation of iPSCs; generation and characterization of cellular and organoid models; application of molecular and cellular biology techniques; microscopy; analysis of gene expression and cellular pathways; gene editing; analysis and interpretation of results; and participation in scientific publications and conferences.

PhD position focused on the study of the molecular, biochemical, and cellular mechanisms involved in neurometabolic diseases, with particular emphasis on propionic acidemia, using human models derived from induced pluripotent stem cells (iPSCs).

The project will include the generation and characterization of cerebral organoids to investigate the molecular and biochemical phenotype associated with the disease, as well as the evaluation of potential therapeutic strategies targeting altered cellular pathways, including pharmacological compounds and miRNA-based approaches.

In addition, the research will address the study and correction of splicing defects caused by variants identified in patients with neurometabolic diseases through the use of antisense oligonucleotides and gene-editing strategies.

Responsibilities will include the culture and differentiation of iPSCs; generation and characterization of cellular and organoid models; application of molecular and cellular biology techniques; microscopy; analysis of gene expression and cellular pathways; gene editing; analysis and interpretation of results; and participation in scientific publications and conferences.

Where to apply Website https://www.uam.es/uam/investigacion/ofertas-empleo/contrato-fpi2026-mam